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Interactions of Renal‐Clearable Gold Nanoparticles with Tumor Microenvironments: Vasculature and Acidity Effects
Author(s) -
Yu Mengxiao,
Zhou Chen,
Liu Li,
Zhang Shanrong,
Sun Shasha,
Hankins Julia D.,
Sun Xiankai,
Zheng Jie
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201612647
Subject(s) - lncap , chemistry , colloidal gold , nanomedicine , nanoparticle , tumor microenvironment , biophysics , prostate cancer , cancer research , nanotechnology , tumor cells , cancer , materials science , medicine , biology
The success of nanomedicines in the clinic depends on our comprehensive understanding of nano–bio interactions in tumor microenvironments, which are characterized by dense leaky microvasculature and acidic extracellular pH (pH e ) values. Herein, we investigated the accumulation of ultrasmall renal‐clearable gold NPs (AuNPs) with and without acidity targeting in xenograft mouse models of two prostate cancer types, PC‐3 and LNCaP, with distinct microenvironments. Our results show that both sets of AuNPs could easily penetrate into the tumors but their uptake and retention were mainly dictated by the tumor microvasculature and the enhanced permeability and retention effect over the entire targeting process. On the other hand, increased tumor acidity indeed enhanced the uptake of AuNPs with acidity targeting, but only for a limited period of time. By making use of simple surface chemistry, these two effects can be synchronized in time for high tumor targeting, opening new possibilities to further improve the targeting efficiencies of nanomedicines.