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Transition‐Metal‐Catalyzed Utilization of Methanol as a C 1 Source in Organic Synthesis
Author(s) -
Natte Kishore,
Neumann Helfried,
Beller Matthias,
Jagadeesh Rajenahally V.
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201612520
Subject(s) - catalysis , transition metal , methanol , organic synthesis , chemistry , materials science , organic chemistry
Methanol is used as a common solvent, cost‐effective reagent, and sustainable feedstock for value‐added chemicals, pharmaceuticals, and materials. Among the various applications, the utilization of methanol as a C 1 source for the formation of carbon–carbon, carbon–nitrogen, and carbon–oxygen bonds continues to be important in organic synthesis and drug discovery. In particular, the synthesis of C‐, N‐, and O‐methylated products is of central interest because these motifs are found in a large number of natural products as well as fine and bulk chemicals. In this Minireview, we summarize the utilization of methanol as a C 1 source in methylation, methoxylation, formylation, methoxycarbonylation, and oxidative methyl ester formation reactions.