Nitroarenes as the Nitrogen Source in Intermolecular Palladium‐Catalyzed Aryl C–H Bond Aminocarbonylation Reactions | Zendy

Zhou Fei | Zendy; Wang DuoSheng | Zendy; Guan Xinyu | Zendy; Driver Tom G. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Nitroarenes as the Nitrogen Source in Intermolecular Palladium‐Catalyzed Aryl C–H Bond Aminocarbonylation Reactions

Author(s) -

Zhou Fei,

Wang DuoSheng,

Guan Xinyu,

Driver Tom G.

Publication year - 2017

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201612324

Subject(s) - intermolecular force , palladium , catalysis , aryl , chemistry , nitrogen , ligand (biochemistry) , surface modification , medicinal chemistry , molecule , combinatorial chemistry , organic chemistry , receptor , alkyl , biochemistry

A three‐component palladium‐catalyzed aminocarbonylation of aryl and heteroaryl sp 2 C−H bonds using nitroarenes as the nitrogen source was achieved using Mo(CO) 6 as the reductant and origin of the CO. This intermolecular C−H bond functionalization does not requires any exogenous ligand to be added, and our mechanism experiments indicate that the palladacycle catalyst serves two roles in the aminocarbonylation reaction: reduce the nitroarene to a nitrosoarene and activate the sp 2 C−H bond.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research