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Nitroarenes as the Nitrogen Source in Intermolecular Palladium‐Catalyzed Aryl C–H Bond Aminocarbonylation Reactions
Author(s) -
Zhou Fei,
Wang DuoSheng,
Guan Xinyu,
Driver Tom G.
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201612324
Subject(s) - palladium , intermolecular force , catalysis , aryl , nitrogen , chemistry , medicinal chemistry , organic chemistry , molecule , alkyl
A three‐component palladium‐catalyzed aminocarbonylation of aryl and heteroaryl sp 2 C−H bonds using nitroarenes as the nitrogen source was achieved using Mo(CO) 6 as the reductant and origin of the CO. This intermolecular C−H bond functionalization does not requires any exogenous ligand to be added, and our mechanism experiments indicate that the palladacycle catalyst serves two roles in the aminocarbonylation reaction: reduce the nitroarene to a nitrosoarene and activate the sp 2 C−H bond.