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Cs 2 CO 3 ‐Catalyzed Aerobic Oxidative Cross‐Dehydrogenative Coupling of Thiols with Phosphonates and Arenes
Author(s) -
Song Song,
Zhang Yiqun,
Yeerlan Adeli,
Zhu Bencong,
Liu Jianzhong,
Jiao Ning
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201612190
Subject(s) - catalysis , molecular oxygen , chemistry , oxidative phosphorylation , alkali metal , oxidative coupling of methane , salt (chemistry) , oxygen , functional group , combinatorial chemistry , molecule , organic chemistry , biochemistry , polymer
An efficient Cs 2 CO 3 ‐catalyzed oxidative coupling of thiols with phosphonates and arenes that uses molecular oxygen as the oxidant is described. These reactions provide not only a novel alkali metal salt catalyzed aerobic oxidation, but also an efficient approach to thiophosphates and sulfenylarenes, which are ubiquitously found in pharmaceuticals and pesticides. The reaction proceeds under simple and mild reaction conditions, tolerates a wide range of functional groups, and is applicable to the late‐stage synthesis and modification of bioactive molecules.