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DNA‐Encoded Compound Libraries as Open Source: A Powerful Pathway to New Drugs
Author(s) -
Lerner Richard A.,
Brenner Sydney
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201612143
Subject(s) - dna , computational biology , computer science , event (particle physics) , identifier , chemistry , nanotechnology , biology , genetics , physics , materials science , programming language , quantum mechanics
“… We envisioned an iterative system where a unique DNA tag identifier that encoded the event was appended to each newly formed molecule. These vast collections of molecules are known today as DNA‐ encoded chemical libraries (DECLs), and allow scientists to do selections on the benchtop that previously required access to large and complex high‐throughput screening centers …” Read more in the Guest Editorial by Richard A. Lerner and Sydney Brenner.