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Synthetic Channel Specifically Inserts into the Lipid Bilayer of Gram‐Positive Bacteria but not that of Mammalian Erythrocytes
Author(s) -
Zhang Min,
Zhu PingPing,
Xin Pengyang,
Si Wen,
Li ZhanTing,
Hou JunLi
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201612093
Subject(s) - insert (composites) , bilayer , lipid bilayer , membrane , bacteria , chemistry , biophysics , transmembrane channels , transmembrane protein , gram negative bacteria , gram positive bacteria , biochemistry , ion channel , biology , materials science , escherichia coli , receptor , gene , voltage gated ion channel , composite material , genetics , antibiotics
A series of tubular molecules with different lengths have been synthesized by attaching Trp‐incorporated peptides to the pillar[5]arene backbone. The tubular molecules are able to insert into the lipid bilayer to form unimolecular transmembrane channels. One of the channels has been revealed to specifically insert into the bilayer of the Gram‐positive bacteria. In contrast, this channel cannot insert into the membranes of the mammalian rat erythrocytes even at the high concentration of 100 μ m . It was further demonstrated that, as a result of this high membrane selectivity, the channel exhibits efficient antimicrobial activity for the Gram‐positive bacteria and very low hemolytic toxicity for mammalian erythrocytes.