Premium
General Enantioselective C−H Activation with Efficiently Tunable Cyclopentadienyl Ligands
Author(s) -
Jia ZhiJun,
Merten Christian,
Gontla Rajesh,
Daniliuc Constantin G.,
Antonchick Andrey P.,
Waldmann Herbert
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201611981
Subject(s) - enantioselective synthesis , cyclopentadienyl complex , combinatorial chemistry , ligand (biochemistry) , chemistry , stereochemistry , drug discovery , catalysis , modular design , computer science , organic chemistry , receptor , biochemistry , operating system
Cyclopentadienyl (Cp) ligands enable efficient steering of various transition‐metal‐catalyzed transformations, in particular enantioselective C−H activation. Currently only few chiral Cp ligands are available. Therefore, a conceptually general approach to chiral Cp ligand discovery would be invaluable as it would enable the discovery of applicable Cp ligands and to efficiently and rapidly vary and tune their structures. Herein, we describe the three‐step gram‐scale synthesis of a structurally diverse and widely applicable chiral Cp ligand collection (JasCp ligands) with highly variable and adjustable structures. Their modular nature and their amenability to rapid structure variation enabled the efficient discovery of ligands for three enantioselective Rh III ‐catalyzed C−H activation reactions, including one unprecedented transformation. This novel approach should enable the discovery of efficient chiral Cp ligands for various further enantioselective transformations.