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Catalytic Ester and Amide to Amine Interconversion: Nickel‐Catalyzed Decarbonylative Amination of Esters and Amides by C−O and C−C Bond Activation
Author(s) -
Yue Huifeng,
Guo Lin,
Liao HsuanHung,
Cai Yunfei,
Zhu Chen,
Rueping Magnus
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201611819
Subject(s) - amination , chemistry , catalysis , amide , nickel , amine gas treating , aryl , organic chemistry , combinatorial chemistry , medicinal chemistry , alkyl
An efficient nickel‐catalyzed decarbonylative amination reaction of aryl and heteroaryl esters has been achieved for the first time. The new amination protocol allows the direct interconversion of esters and amides into the corresponding amines and represents a good alternative to classical rearrangements as well as cross coupling reactions.