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Micromotors Spontaneously Neutralize Gastric Acid for pH‐Responsive Payload Release
Author(s) -
Li Jinxing,
Angsantikul Pavimol,
Liu Wenjuan,
EstebanFernández de Ávila Berta,
Thamphiwatana Soracha,
Xu Mingli,
Sandraz Elodie,
Wang Xiaolei,
Delezuk Jorge,
Gao Weiwei,
Zhang Liangfang,
Wang Joseph
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201611774
Subject(s) - payload (computing) , gastric fluid , gastric acid , stomach , chemistry , biochemistry , chromatography , computer science , computer network , network packet
Abstract The highly acidic gastric environment creates a physiological barrier for using therapeutic drugs in the stomach. While proton pump inhibitors have been widely used for blocking acid‐producing enzymes, this approach can cause various adverse effects. Reported herein is a new microdevice, consisting of magnesium‐based micromotors which can autonomously and temporally neutralize gastric acid through efficient chemical propulsion in the gastric fluid by rapidly depleting the localized protons. Coating these micromotors with a cargo‐containing pH‐responsive polymer layer leads to autonomous release of the encapsulated payload upon gastric‐acid neutralization by the motors. Testing in a mouse model demonstrate that these motors can safely and rapidly neutralize gastric acid and simultaneously release payload without causing noticeable acute toxicity or affecting the stomach function, and the normal stomach pH is restored within 24 h post motor administration.