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Rational Design and Synthesis of Efficient Sunscreens To Boost the Solar Protection Factor
Author(s) -
Losantos Raúl,
FunesArdoiz Ignacio,
Aguilera José,
HerreraCeballos Enrique,
GarcíaIriepa Cristina,
Campos Pedro J.,
Sampedro Diego
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201611627
Subject(s) - sun protection factor , rational design , erythema , sun protection , biochemical engineering , nanotechnology , materials science , computer science , dermatology , medicine , engineering
Skin cancer incidence has been increasing in the last decades, but most of the commercial formulations used as sunscreens are designed to protect only against solar erythema. Many of the active components present in sunscreens show critical weaknesses, such as low stability and toxicity. Thus, the development of more efficient components is an urgent health necessity and an attractive industrial target. We have rationally designed core moieties with increased photoprotective capacities and a new energy dissipation mechanism. Using these scaffolds, we have synthesized a series of compounds with tunable properties suitable for their use in sunscreens, and enhanced properties in terms of stability, light energy dissipation, and toxicity. Moreover, some representative compounds were included in final sunscreen formulations and a relevant solar protection factor boost was measured.