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Hydrodehalogenation of Haloarenes by a Sodium Hydride–Iodide Composite
Author(s) -
Ong Derek Yiren,
Tejo Ciputra,
Xu Kai,
Hirao Hajime,
Chiba Shunsuke
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201611495
Subject(s) - iodide , sodium hydride , chemistry , sodium iodide , hydride , lithium (medication) , nucleophile , sodium , nucleophilic substitution , iodine , lithium hydride , medicinal chemistry , inorganic chemistry , organic chemistry , catalysis , ion , ionic bonding , metal , medicine , endocrinology
A simple protocol for hydrodebromination and ‐deiodination of halo(hetero)arenes was enabled by sodium hydride (NaH) in the presence of lithium iodide (LiI). Mechanistic studies showed that an unusual concerted nucleophilic aromatic substitution operates in the present process.