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Cation‐Selective Channel Regulated by Anions According to Their Hofmeister Ranking
Author(s) -
Gurnev Philip A.,
Roark Torri C.,
Petrache Horia I.,
Sodt Alexander J.,
Bezrukov Sergey M.
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201611335
Subject(s) - chemistry , hofmeister series , chaotropic agent , lipid bilayer , gramicidin , dissociation (chemistry) , conductance , context (archaeology) , kinetics , bilayer , membrane , ion , chemical physics , chromatography , biochemistry , organic chemistry , paleontology , physics , mathematics , combinatorics , quantum mechanics , biology
Specificity of small ions, the Hofmeister ranking, is long‐known and has many applications including medicine. Yet it evades consistent theoretical description. Here we study the effect of Hofmeister anions on gramicidin A channels in lipid membranes. Counterintuitively, we find that conductance of this perfectly cation‐selective channel increases about two‐fold in the H 2 PO 4 −