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Rethinking the Claisen–Tishchenko Reaction
Author(s) -
Morris Stacey A.,
Gusev Dmitry G.
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201611186
Subject(s) - disproportionation , bifunctional , chemistry , catalysis , pincer movement , medicinal chemistry , stereochemistry , organic chemistry
Pincer‐type complexes [OsH 2 (CO){PyCH 2 NHCH 2 CH 2 NHP t Bu 2 }] and [OsH 2 (CO){HN(CH 2 CH 2 P i Pr 2 ) 2 }] catalyze the disproportionation reaction of aldehydes via an outer‐sphere bifunctional mechanism achieving turnover frequencies up to 14 000 h −1 . The N−H group of the catalysts is a key player in this process, elucidated with the help of DFT calculations.
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