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Transient Helicity: Fuel‐Driven Temporal Control over Conformational Switching in a Supramolecular Polymer
Author(s) -
Dhiman Shikha,
Jain Ankit,
George Subi J.
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201610946
Subject(s) - supramolecular chemistry , helicity , dissipative system , modular design , transient (computer programming) , conformational change , chirality (physics) , chemical physics , chemistry , biophysics , materials science , computer science , stereochemistry , crystallography , physics , thermodynamics , biology , crystal structure , nambu–jona lasinio model , chiral symmetry breaking , particle physics , quantum mechanics , quark , operating system
Synthetic manifestations of supramolecular chirality have extensively drawn inspiration from naturally occurring systems. Even though in biological systems conformational changes are dissipative, synthetic systems that change conformation under non‐equilibrium conditions have still not been established. Herein, we attempt to alleviate this scenario by reporting a synthetic supramolecular system that undergoes temporal changes in its helical conformation as an active system at the expense of a biologically relevant chemical fuel, ATP. Use of enzymes working in tandem provides transient and switchable helices with modular lifetime and stereomutation rates.