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Glucose‐Responsive Sequential Generation of Hydrogen Peroxide and Nitric Oxide for Synergistic Cancer Starving‐Like/Gas Therapy
Author(s) -
Fan Wenpei,
Lu Nan,
Huang Peng,
Liu Yi,
Yang Zhen,
Wang Sheng,
Yu Guocan,
Liu Yijing,
Hu Junkai,
He Qianjun,
Qu Junle,
Wang Tianfu,
Chen Xiaoyuan
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201610682
Subject(s) - glucose oxidase , hydrogen peroxide , nanocarriers , chemistry , gluconic acid , nanomedicine , nitric oxide , cancer therapy , nanoparticle , photodynamic therapy , biocompatible material , combinatorial chemistry , biochemistry , cancer , nanotechnology , organic chemistry , materials science , drug delivery , biomedical engineering , medicine , biosensor
Glucose is a key energy supplier and nutrient for tumor growth. Herein, inspired by the glucose oxidase (GOx)‐assisted conversion of glucose into gluconic acid and toxic H 2 O 2 , a novel treatment paradigm of starving‐like therapy is developed for significant tumor‐killing effects, more effective than conventional starving therapy by only cutting off the energy supply. Furthermore, the generated acidic H 2 O 2 can oxidize l ‐Arginine ( l ‐Arg) into NO for enhanced gas therapy. By using hollow mesoporous organosilica nanoparticle (HMON) as a biocompatible/biodegradable nanocarrier for the co‐delivery of GOx and l ‐Arg, a novel glucose‐responsive nanomedicine ( l ‐Arg‐HMON‐GOx) has been for the first time constructed for synergistic cancer starving‐like/gas therapy without the need of external excitation, which yields a remarkable H 2 O 2 –NO cooperative anticancer effect with minimal adverse effect.