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Synthesis of Bradyrhizose Oligosaccharides Relevant to the Bradyrhizobium O‐Antigen
Author(s) -
Li Wei,
Silipo Alba,
Gersby Lotte Bettina Andersen,
Newman MariAnne,
Molinaro Antonio,
Yu Biao
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201610680
Subject(s) - bradyrhizobium , glycosylation , innate immune system , antigen , immune system , chemistry , biology , microbiology and biotechnology , computational biology , biochemistry , symbiosis , immunology , bacteria , genetics
Abstract The unique α‐(1→7)‐bradyrhizoside linkages are constructed for the first time via judicious choice of the glycosylation partners and conditions, thus tetra‐ and penta‐bradyrhizosides relevant to the peculiar O‐antigen of Bradyrhizobium are synthesized, which are shown to adopt the defined right‐handed helical conformations and to be unable to induce innate immune responses in plants.