Ligand‐Enabled Alkynylation of C(sp 3 )−H Bonds with Palladium(II) Catalysts | Zendy

Fu Haiyan | Zendy; Shen PengXiang | Zendy; He Jian | Zendy; Zhang Fanglin | Zendy; Li Suhua | Zendy; Wang Peng | Zendy; Liu Tao | Zendy; Yu JinQuan | Zendy

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Ligand‐Enabled Alkynylation of C(sp 3 )−H Bonds with Palladium(II) Catalysts

Author(s) -

Fu Haiyan,

Shen PengXiang,

He Jian,

Zhang Fanglin,

Li Suhua,

Wang Peng,

Liu Tao,

Yu JinQuan

Publication year - 2017

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201610426

Subject(s) - alkynylation , palladium , catalysis , chemistry , pyridine , ligand (biochemistry) , amide , methylene , medicinal chemistry , palladium catalyst , polymer chemistry , organic chemistry , receptor , biochemistry

The palladium(II)‐catalyzed β‐ and γ‐alkynylation of amide C(sp 3 )−H bonds is enabled by pyridine‐based ligands. This alkynylation reaction is compatible with substrates containing α‐tertiary or α‐quaternary carbon centers. The β‐methylene C(sp 3 )−H bonds of various carbocyclic rings were also successfully alkynylated.

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