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Ligand‐Enabled Alkynylation of C(sp 3 )−H Bonds with Palladium(II) Catalysts
Author(s) -
Fu Haiyan,
Shen PengXiang,
He Jian,
Zhang Fanglin,
Li Suhua,
Wang Peng,
Liu Tao,
Yu JinQuan
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201610426
Subject(s) - alkynylation , palladium , catalysis , chemistry , pyridine , ligand (biochemistry) , amide , methylene , medicinal chemistry , palladium catalyst , polymer chemistry , organic chemistry , receptor , biochemistry
The palladium(II)‐catalyzed β‐ and γ‐alkynylation of amide C(sp 3 )−H bonds is enabled by pyridine‐based ligands. This alkynylation reaction is compatible with substrates containing α‐tertiary or α‐quaternary carbon centers. The β‐methylene C(sp 3 )−H bonds of various carbocyclic rings were also successfully alkynylated.