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In Vivo Gold Complex Catalysis within Live Mice
Author(s) -
Tsubokura Kazuki,
Vong Kenward K. H.,
Pradipta Ambara R.,
Ogura Akihiro,
Urano Sayaka,
Tahara Tsuyoshi,
Nozaki Satoshi,
Onoe Hirotaka,
Nakao Yoichi,
Sibgatullina Regina,
Kurbangalieva Almira,
Watanabe Yasuyoshi,
Tanaka Katsunori
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201610273
Subject(s) - propargyl , catalysis , in vivo , combinatorial chemistry , chemistry , nanotechnology , reactivity (psychology) , fluorescence , biochemistry , biology , materials science , microbiology and biotechnology , medicine , alternative medicine , pathology , physics , quantum mechanics
Metal complex catalysis within biological systems is largely limited to cell and bacterial systems. In this work, a glycoalbumin–Au III complex was designed and developed that enables organ‐specific, localized propargyl ester amidation with nearby proteins within live mice. The targeted reactivity can be imaged through the use of Cy7.5‐ and TAMRA‐linked propargyl ester based fluorescent probes. This targeting system could enable the exploitation of other metal catalysis strategies for biomedical and clinical applications.