Premium
Regio‐ and Enantioselective Cobalt‐Catalyzed Sequential Hydrosilylation/Hydrogenation of Terminal Alkynes
Author(s) -
Guo Jun,
Shen Xuzhong,
Lu Zhan
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201610121
Subject(s) - hydrosilylation , silanes , regioselectivity , enantioselective synthesis , catalysis , cobalt , organic chemistry , chemistry , combinatorial chemistry , silane
A highly regio‐ and enantioselective cobalt‐catalyzed sequential hydrosilylation/hydrogenation of alkynes was developed to afford chiral silanes. This one‐pot method is operationally simple and atom economic. It makes use of relatively simple and readily available starting materials, namely alkynes, silanes, and hydrogen gas, to construct more valuable chiral silanes. Primary mechanistic studies demonstrated that highly regioselective hydrosilylation of alkynes with silanes occurred as a first step, and the subsequent cobalt‐catalyzed asymmetric hydrogenation of the resulting vinylsilanes showed good enantioselectivity.