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Combination of Cp*Rh III ‐Catalyzed C−H Activation and a Wagner–Meerwein‐Type Rearrangement
Author(s) -
Wang Xiaoming,
Lerchen Andreas,
Gensch Tobias,
Knecht Tobias,
Daniliuc Constantin G.,
Glorius Frank
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201610117
Subject(s) - catalysis , chemistry , stereochemistry , rhodium , medicinal chemistry , organic chemistry
A combination of Cp*Rh III ‐catalyzed C−H activation and Wagner–Meerwein‐type rearrangement was successfully achieved for the first time. Thus, bridged polycyclic molecules that are not readily accessible by other means were accessed under mild conditions with high efficiency (as low as 0.5 mol % Rh catalyst) in the coupling of N ‐phenoxyacetamide with 7‐azabenzonorbornadiene.