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PhSO 2 SCF 2 H: A Shelf‐Stable, Easily Scalable Reagent for Radical Difluoromethylthiolation
Author(s) -
Zhu Dianhu,
Shao Xinxin,
Hong Xin,
Lu Long,
Shen Qilong
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201609468
Subject(s) - reagent , chemistry , aryl , alkyl , combinatorial chemistry , organic chemistry
A new shelf‐stable and easily scalable difluoromethylthiolating reagent S ‐(difluoromethyl) benzenesulfonothioate (PhSO 2 SCF 2 H) was developed. PhSO 2 SCF 2 H is a powerful reagent for radical difluoromethylthiolation of aryl and alkyl boronic acids, decarboxylative difluoromethylthiolation of aliphatic acids, and a phenylsulfonyl‐difluoromethylthio difunctionalization of alkenes under mild reaction conditions.