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Modern Synthetic Avenues for the Preparation of Functional Fluorophores
Author(s) -
de Moliner Fabio,
Kielland Nicola,
Lavilla Rodolfo,
Vendrell Marc
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201609394
Subject(s) - biomolecule , nanotechnology , profiling (computer programming) , computer science , biochemical engineering , synthetic biology , chemistry , computational biology , materials science , biology , engineering , operating system
Biomedical research relies on the fast and accurate profiling of specific biomolecules and cells in a non‐invasive manner. Functional fluorophores are powerful tools for such studies. As these sophisticated structures are often difficult to access through conventional synthetic strategies, new chemical processes have been developed in the past few years. In this Minireview, we describe the most recent advances in the design, preparation, and fine‐tuning of fluorophores by means of multicomponent reactions, C−H activation processes, cycloadditions, and biomolecule‐based chemical transformations.