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A Hyperpolarizable 1 H Magnetic Resonance Probe for Signal Detection 15 Minutes after Spin Polarization Storage
Author(s) -
Roy Soumya S.,
Norcott Philip,
Rayner Peter J.,
Green Gary G. R.,
Duckett Simon B.
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201609186
Subject(s) - hyperpolarization (physics) , polarization (electrochemistry) , nuclear magnetic resonance , magnetic resonance imaging , signal (programming language) , induced polarization , magnetic resonance force microscopy , chemistry , physics , nuclear magnetic resonance spectroscopy , magnetic field , computer science , ferromagnetic resonance , medicine , quantum mechanics , radiology , programming language , electrical resistivity and conductivity , magnetization
Abstract Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) are two extremely important techniques with applications ranging from molecular structure determination to human imaging. However, in many cases the applicability of NMR and MRI are limited by inherently poor sensitivity and insufficient nuclear spin lifetime. Here we demonstrate a cost‐efficient and fast technique that tackles both issues simultaneously. We use the signal amplification by reversible exchange (SABRE) technique to hyperpolarize the target 1 H nuclei and store this polarization in long‐lived singlet (LLS) form after suitable radiofrequency (rf) pulses. Compared to the normal scenario, we achieve three orders of signal enhancement and one order of lifetime extension, leading to 1 H NMR signal detection 15 minutes after the creation of the detected states. The creation of such hyperpolarized long‐lived polarization reflects an important step forward in the pipeline to see such agents used as clinical probes of disease.