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Tailoring Renal Clearance and Tumor Targeting of Ultrasmall Metal Nanoparticles with Particle Density
Author(s) -
Tang Shaoheng,
Peng Chuanqi,
Xu Jing,
Du Bujie,
Wang Qingxiao,
Vinluan Rodrigo D.,
Yu Mengxiao,
Kim Moon J.,
Zheng Jie
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201609043
Subject(s) - in vivo , nanoparticle , nanomaterials , materials science , nanotechnology , particle size , particle (ecology) , metal , biophysics , chemistry , oceanography , microbiology and biotechnology , geology , metallurgy , biology
Identifying key factors that govern the in vivo behavior of nanomaterials is critical to the clinical translation of nanomedicines. Overshadowed by size‐, shape‐, and surface‐chemistry effects, the impact of the particle core density on clearance and tumor targeting of inorganic nanoparticles (NPs) remains largely unknown. By utilizing a class of ultrasmall metal NPs with the same size and surface chemistry but different densities, we found that the renal‐clearance efficiency exponentially increased in the early elimination phase while passive tumor targeting linearly decreased with a decrease in particle density. Moreover, lower‐density NPs are more easily distributed in the body and have shorter retention times in highly permeable organs than higher‐density NPs. The density‐dependent in vivo behavior of metal NPs likely results from their distinct margination in laminar blood flow, which opens up a new path for precise control of nanomedicines in vivo.