Construction of Chiral Tetraorganosilicons by Tandem Desymmetrization of Silacyclobutanes/Intermolecular Dehydrogenative Silylation | Zendy

Zhang QingWei | Zendy; An Kun | Zendy; Liu LiChuan | Zendy; Zhang Qi | Zendy; Guo Huifang | Zendy; He Wei | Zendy

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Construction of Chiral Tetraorganosilicons by Tandem Desymmetrization of Silacyclobutanes/Intermolecular Dehydrogenative Silylation

Author(s) -

Zhang QingWei,

An Kun,

Liu LiChuan,

Zhang Qi,

Guo Huifang,

He Wei

Publication year - 2017

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201609022

Subject(s) - desymmetrization , stereocenter , tandem , silylation , chemistry , intermolecular force , reactivity (psychology) , ligand (biochemistry) , stereochemistry , combinatorial chemistry , organic chemistry , enantioselective synthesis , catalysis , molecule , materials science , biochemistry , medicine , alternative medicine , receptor , pathology , composite material

We report a method to construct chiral tetraorganosilicons by tandem silacyclobutane (SCB) desymmetrization–dehydrogenative silylations. A wide array of dibenzosiloles with stereogenic quaternary silicon centers were obtained in good yields and enantioselectivities up to 93 % ee . Chiral TMS‐segphos was found to be a superior ligand in terms of reactivity and enantioselectivity.

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