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Terpene Cyclases from Social Amoebae
Author(s) -
Rabe Patrick,
Rinkel Jan,
Nubbemeyer Britta,
Köllner Tobias G.,
Chen Feng,
Dickschat Jeroen S.
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201608971
Subject(s) - terpene , dictyostelium discoideum , enzyme , chemistry , biology , stereochemistry , biochemistry , botany , gene
Genome sequences of social amoebae reveal the presence of terpene cyclases (TCs) in these organisms. Two TCs from Dictyostelium discoideum converted farnesyl diphosphate into (2 S ,3 R ,6 S ,9 S )‐(−)‐protoillud‐7‐ene and (3 S )‐(+)‐asterisca‐2(9),6‐diene. The enzyme mechanisms and EI‐MS fragmentations of the products were studied by labeling experiments.