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(C 6 F 5 ) 3 B Catalyzed Chemoselective and ortho ‐Selective Substitution of Phenols with α‐Aryl α‐Diazoesters
Author(s) -
Yu Zhunzhun,
Li Yongfeng,
Shi Jiameng,
Ma Ben,
Liu Lu,
Zhang Junliang
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201608937
Subject(s) - phenols , aryl , substitution (logic) , catalysis , scope (computer science) , substrate (aquarium) , chemistry , combinatorial chemistry , reaction conditions , medicinal chemistry , organic chemistry , computer science , alkyl , oceanography , programming language , geology
The development of an efficient method for the site‐selective substitution of unprotected phenols has long been considered as an attractive but challenging task. Herein, we describe a highly chemo‐ and ortho ‐selective substitution reaction of phenols with α‐aryl α‐diazoacetates with commercially available (C 6 F 5 ) 3 B as the catalyst. This reaction proceeds under simple and mild conditions with high efficiency, it features a wide substrate scope and can be easily scaled up.