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Inside Cover: A One‐Pot Chemically Cleavable Bis‐Linker Tether Strategy for the Synthesis of Heterodimeric Peptides (Angew. Chem. Int. Ed. 47/2016)
Author(s) -
Patil Nitin A.,
Tailhades Julien,
Karas John A.,
Separovic Frances,
Wade John D.,
Hossain Mohammed Akhter
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201608906
Subject(s) - linker , folding (dsp implementation) , chemistry , peptide , cover (algebra) , combinatorial chemistry , yield (engineering) , solid phase synthesis , stereochemistry , nanotechnology , biochemistry , materials science , computer science , mechanical engineering , engineering , operating system , electrical engineering , metallurgy
Cystine‐Rich heterodimeric peptides or proteins (e.g. insulin) are attractive drug targets. However, their chemical assembly and correct folding is complex, time consuming, and often low yielding. In their Communication on page 14552 ff., J. Tailhades, J. D. Wade, M. A. Hossain, and co‐workers describe a novel strategy in which two peptide chains are sequentially assembled on a solid support separated by a bis‐linker tether. Following folding, the tether is removed by hydrazinolysis to produce the peptide in high yield and less time.