Iron‐Catalyzed Mild and Selective Hydrogenative Cross‐Coupling of Nitriles and Amines To Form Secondary Aldimines | Zendy

Chakraborty Subrata | Zendy; Leitus Gregory | Zendy; Milstein David | Zendy

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Iron‐Catalyzed Mild and Selective Hydrogenative Cross‐Coupling of Nitriles and Amines To Form Secondary Aldimines

Author(s) -

Chakraborty Subrata,

Leitus Gregory,

Milstein David

Publication year - 2017

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201608537

Subject(s) - aldimine , catalysis , homogeneous , chemistry , base (topology) , pincer movement , coupling (piping) , organic chemistry , combinatorial chemistry , polymer chemistry , medicinal chemistry , materials science , mathematics , mathematical analysis , combinatorics , metallurgy

The first example of a base‐metal‐catalyzed homogeneous hydrogenative coupling of nitriles and amines to selectively form secondary cross‐imines is reported. The reaction is catalyzed under mild conditions by a well‐defined (iPr‐PNP)Fe(H)Br(CO) pincer pre‐catalyst and catalytic t BuOK.

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