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Iron‐Catalyzed Mild and Selective Hydrogenative Cross‐Coupling of Nitriles and Amines To Form Secondary Aldimines
Author(s) -
Chakraborty Subrata,
Leitus Gregory,
Milstein David
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201608537
Subject(s) - aldimine , catalysis , homogeneous , chemistry , base (topology) , pincer movement , coupling (piping) , organic chemistry , combinatorial chemistry , polymer chemistry , medicinal chemistry , materials science , mathematics , mathematical analysis , combinatorics , metallurgy
The first example of a base‐metal‐catalyzed homogeneous hydrogenative coupling of nitriles and amines to selectively form secondary cross‐imines is reported. The reaction is catalyzed under mild conditions by a well‐defined (iPr‐PNP)Fe(H)Br(CO) pincer pre‐catalyst and catalytic t BuOK.