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The First Organocatalytic Cope Rearrangement
Author(s) -
Gebauer Konrad,
Schneider Christoph
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201608508
Subject(s) - iminium , catalysis , organocatalysis , chemistry , cope rearrangement , combinatorial chemistry , stereochemistry , organic chemistry , enantioselective synthesis
Exploiting the concept of iminium ion catalysis led to the discovery of the first organocatalytic Cope rearrangement of 1,5‐hexadiene‐2‐carboxaldehydes. A diazepane catalyst exhibited optimal catalytic efficiency and offers possibilities for chiral modification.