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Catalytic Asymmetric Reductive Condensation of N–H Imines: Synthesis of C 2 ‐Symmetric Secondary Amines
Author(s) -
Wakchaure Vijay N.,
List Benjamin
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201608329
Subject(s) - enantioselective synthesis , catalysis , condensation , chemistry , brønsted–lowry acid–base theory , hydrogen , organic chemistry , combinatorial chemistry , condensation reaction , medicinal chemistry , physics , thermodynamics
A highly diastereoselective and enantioselective Brønsted acid catalyzed reductive condensation of N−H imines was developed. This reaction is catalyzed by a chiral disulfonimide (DSI), uses Hantzsch esters as a hydrogen source, and delivers useful C 2 ‐symmetric secondary amines.