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Access to Acyclic Z ‐Enediynes by Alkyne Trimerization: Cooperative Bimetallic Catalysis Using Air as the Oxidant
Author(s) -
Lee Jin Tu Danence,
Zhao Yu
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201608192
Subject(s) - alkyne , bimetallic strip , enediyne , moiety , combinatorial chemistry , catalysis , chemistry , yield (engineering) , palladium , organic chemistry , materials science , metallurgy
Presented herein is a mild, operationally simple, mix‐and‐go procedure for the synthesis of acyclic trisubstituted Z ‐enediynes, from readily available terminal alkynes, in good yields. This method stems from a serendipitous discovery, and makes use of cooperative palladium/copper bimetallic catalysis and air as an oxidant to effect an intriguing alkyne trimerization to yield the valuable Z ‐enediyne moiety.