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Preparation of Vinyl Arenes by Nickel‐Catalyzed Reductive Coupling of Aryl Halides with Vinyl Bromides
Author(s) -
Liu Jiandong,
Ren Qinghua,
Zhang Xinghua,
Gong Hegui
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201607959
Subject(s) - chemoselectivity , halide , aryl , catalysis , nickel , chemistry , reductive elimination , combinatorial chemistry , coupling reaction , organic chemistry , polymer chemistry , alkyl
This work emphasizes the synthesis of substituted vinyl arenes by reductive coupling of aryl halides with vinyl bromides under mild and easy‐to‐operate nickel‐catalyzed reaction conditions. A broad range of aryl halides, including heteroaromatics, and vinyl bromides were employed to yielding products in moderate to excellent yields with high functional‐group tolerance. The nickel‐catalytic system displays good chemoselectivity between the two C(sp 2 )‐halide coupling partners, thus demonstrating a mechanistic pathway distinct from other stepwise protocols.