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Directed Evolution of Iridium‐Substituted Myoglobin Affords Versatile Artificial Metalloenzymes for Enantioselective C−C Bond‐Forming Reactions
Author(s) -
Ward Thomas R.
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201607222
Subject(s) - myoglobin , iridium , enantioselective synthesis , intramolecular force , chemistry , combinatorial chemistry , photochemistry , catalysis , stereochemistry , organic chemistry
Upgrading myoglobin with iridium : A metal‐substitution strategy has been used to afford a repurposed myoglobin for challenging cyclopropanation and intramolecular C−H activation reactions. The performance of the iridium‐loaded myoglobin (orange sphere) was improved through directed evolution of eight active‐site residues (yellow surface).