Construction of Quaternary Stereocenters by Nickel‐Catalyzed Heck Cyclization Reactions | Zendy

Desrosiers JeanNicolas | Zendy; Hie Liana | Zendy; Biswas Soumik | Zendy; Zatolochnaya Olga V. | Zendy; Rodriguez Sonia | Zendy; Lee Heewon | Zendy; Grinberg Nelu | Zendy; Haddad Nizar | Zendy; Yee Nathan K. | Zendy; Garg Neil K. | Zendy; Senanayake Chris H. | Zendy

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Construction of Quaternary Stereocenters by Nickel‐Catalyzed Heck Cyclization Reactions

Author(s) -

Desrosiers JeanNicolas,

Hie Liana,

Biswas Soumik,

Zatolochnaya Olga V.,

Rodriguez Sonia,

Lee Heewon,

Grinberg Nelu,

Haddad Nizar,

Yee Nathan K.,

Garg Neil K.,

Senanayake Chris H.

Publication year - 2016

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201606955

Subject(s) - stereocenter , nickel , catalysis , combinatorial chemistry , heck reaction , chemistry , scope (computer science) , molecule , palladium , enantioselective synthesis , organic chemistry , computer science , programming language

A nickel‐catalyzed Heck cyclization for the construction of quaternary stereocenters is reported. This transformation is demonstrated in the synthesis of 3,3‐disubstituted oxindoles, which are prevalent motifs seen in numerous biologically active molecules. The method shows broad scope, proceeds in synthetically useful yields, and provides a rare means to construct stereochemically complex frameworks by nonprecious‐metal catalysis.

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