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Spontaneous Assembly of an Organic–Inorganic Nucleic Acid Z‐DNA Double‐Helix Structure
Author(s) -
Kulikov Vladislav,
Johnson Naomi A. B.,
Surman Andrew J.,
Hutin Marie,
Kelly Sharon M.,
Hezwani Mohammed,
Long DeLiang,
Meyer Gerd,
Cronin Leroy
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201606658
Subject(s) - dimer , crystallography , covalent bond , nucleic acid , guanosine , helix (gastropod) , circular dichroism , chemistry , dna , monomer , stereochemistry , base pair , adduct , g quadruplex , polymer , organic chemistry , biochemistry , biology , ecology , snail
Herein, we report a hybrid polyoxometalate organic–inorganic compound, Na 2 [(HGMP) 2 Mo 5 O 15 ]⋅7 H 2 O ( 1 ; where GMP=guanosine monophosphate), which spontaneously assembles into a structure with dimensions that are strikingly similar to those of the naturally occurring left‐handed Z‐form of DNA. The helical parameters in the crystal structure of the new compound, such as rise per turn and helical twist per dimer, are nearly identical to this DNA conformation, allowing a close comparison of the two structures. Solution circular dichroism studies show that compound 1 also forms extended secondary structures in solution. Gel electrophoresis studies demonstrate the formation of non‐covalent adducts with natural plasmids. Thus we show a route by which simple hybrid inorganic–organic monomers, such as compound 1 , can spontaneously assemble into a double helix without the need for a covalently connected linear sequence of nucleic acid base pairs.