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Cover Picture: Selective Synthesis of Partially Protected Nonsymmetric Biphenols by Reagent‐ and Metal‐Free Anodic Cross‐Coupling Reaction (Angew. Chem. Int. Ed. 39/2016)
Author(s) -
Wiebe Anton,
Schollmeyer Dieter,
Dyballa Katrin M.,
Franke Robert,
Waldvogel Siegfried R.
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201606627
Subject(s) - reagent , chemistry , solvent , yield (engineering) , oxide , materials science , polymer chemistry , organic chemistry , metallurgy
Rotation about the biaryl axis leads to higher yield and selectivity in the electrochemical cross‐coupling giving partially protected 2,2′‐biphenols. In their Communication on page 11801 ff. S. Waldvogel and co‐workers report the first direct synthesis of partially protected nonsymmetric biphenols by oxidative cross‐coupling. The combination of the bulky triisopropylsilyl (TIPS) group and the solvent 1,1,1,3,3,3‐hexafluoropropan‐2‐ol greatly broadens the scope of this sustainable synthesis.