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Back Cover: Nickel‐Catalyzed Reductive Amidation of Unactivated Alkyl Bromides (Angew. Chem. Int. Ed. 37/2016)
Author(s) -
Serrano Eloisa,
Martin Ruben
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201606539
Subject(s) - chemoselectivity , nickel , catalysis , alkyl , catalytic cycle , chemistry , amide , cover (algebra) , organic chemistry , combinatorial chemistry , medicinal chemistry , engineering , mechanical engineering
The mighty dragon, representing a nickel catalyst, combines the starting materials (isocyanates and unactivated alkyl bromides) with his claws to afford the final aliphatic amide products in his fire breath, as described by R. Martin and E. Serrano in their Communication on page 11207 ff. The versatile reaction proceeds under mild conditions and has excellent chemoselectivity. The catalytic cycle and the regeneration of the Ni catalyst in the course of the cycle are represented by the ouroboros‐like image, itself a symbol of cyclicality.