Premium
Back Cover: Asymmetric Ring Opening/Cyclization/Retro‐Mannich Reaction of Cyclopropyl Ketones with Aryl 1,2‐Diamines for the Synthesis of Benzimidazole Derivatives (Angew. Chem. Int. Ed. 40/2016)
Author(s) -
Xia Yong,
Lin Lili,
Chang Fenzhen,
Liao Yuting,
Liu Xiaohua,
Feng Xiaoming
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201606534
Subject(s) - benzimidazole , mannich reaction , ring (chemistry) , chemistry , aryl , reagent , stereochemistry , cover (algebra) , medicinal chemistry , combinatorial chemistry , catalysis , organic chemistry , mechanical engineering , alkyl , engineering
The first asymmetric ring‐opening/cyclization/retro‐Mannich reaction of cyclopropyl ketones with aryl‐1,2‐diamines is described by X. M. Feng, X. H. Liu and co‐workers in their Communication on page 12228 ff. The construction of benzimidazole backbones and establishing the stereochemistry in their side chains are accomplished in only one step in the presence of a N , N ′‐dioxide/Sc III complex. ‘‘The carp has leaped through the dragon's gate’’ means success in a Chinese saying. The N , N ′‐dioxide/Sc III complex is the dragon's gate, the reagents are the carp, and the successfully generated product is the dragon.