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Inside Back Cover: A Bioorthogonal Approach for the Preparation of a Titanium‐Binding Insulin‐like Growth‐Factor‐1 Derivative by Using Tyrosinase (Angew. Chem. Int. Ed. 38/2016)
Author(s) -
Zhang Chen,
Miyatake Hideyuki,
Wang Yu,
Inaba Takehiko,
Wang Yi,
Zhang Peibiao,
Ito Yoshihiro
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201606145
Subject(s) - bioorthogonal chemistry , titanium , tyrosinase , cover (algebra) , growth factor , chemistry , peptide , receptor , click chemistry , combinatorial chemistry , biochemistry , enzyme , organic chemistry , engineering , mechanical engineering
Enhanced cell growth occurs on a titanium surface modified with insulin‐like growth‐factor‐1 prepared by a bioorthogonal approach combining protein engineering and enzyme modification, as shown by Y. Ito and co‐workers in their Communication on page 11447 ff. The picture shows a peptide sequence (center), which is inspired by an underwater adhesion protein (represented as a strong man) secreted by mussels, binding to a dental implant (right) representing titanium‐based medical devices, and to a growth factor stimulating a cell through the receptor (left).