Inside Back Cover: A Bioorthogonal Approach for the Preparation of a Titanium‐Binding Insulin‐like Growth‐Factor‐1 Derivative by Using Tyrosinase (Angew. Chem. Int. Ed. 38/2016) | Zendy

Zhang Chen | Zendy; Miyatake Hideyuki | Zendy; Wang Yu | Zendy; Inaba Takehiko | Zendy; Wang Yi | Zendy; Zhang Peibiao | Zendy; Ito Yoshihiro | Zendy

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Inside Back Cover: A Bioorthogonal Approach for the Preparation of a Titanium‐Binding Insulin‐like Growth‐Factor‐1 Derivative by Using Tyrosinase (Angew. Chem. Int. Ed. 38/2016)

Author(s) -

Zhang Chen,

Miyatake Hideyuki,

Wang Yu,

Inaba Takehiko,

Wang Yi,

Zhang Peibiao,

Ito Yoshihiro

Publication year - 2016

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Reports

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201606145

Subject(s) - bioorthogonal chemistry , titanium , tyrosinase , cover (algebra) , growth factor , chemistry , peptide , receptor , click chemistry , combinatorial chemistry , biochemistry , enzyme , organic chemistry , engineering , mechanical engineering

Enhanced cell growth occurs on a titanium surface modified with insulin‐like growth‐factor‐1 prepared by a bioorthogonal approach combining protein engineering and enzyme modification, as shown by Y. Ito and co‐workers in their Communication on page 11447 ff. The picture shows a peptide sequence (center), which is inspired by an underwater adhesion protein (represented as a strong man) secreted by mussels, binding to a dental implant (right) representing titanium‐based medical devices, and to a growth factor stimulating a cell through the receptor (left).

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