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Inside Cover: Selective Protein Hyperpolarization in Cell Lysates Using Targeted Dynamic Nuclear Polarization (Angew. Chem. Int. Ed. 36/2016)
Author(s) -
Viennet Thibault,
Viegas Aldino,
Kuepper Arne,
Arens Sabine,
Gelev Vladimir,
Petrov Ognyan,
Grossmann Tom N.,
Heise Henrike,
Etzkorn Manuel
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201606093
Subject(s) - hyperpolarization (physics) , polarization (electrochemistry) , chemistry , cover (algebra) , chemical biology , biophysics , nuclear magnetic resonance spectroscopy , physics , biochemistry , biology , stereochemistry , engineering , mechanical engineering
Directing hyperpolarization to a target protein makes it possible to selectively filter out signals of specific proteins from a large background. In their Communication on page 10746 ff., M. Etzkorn et al. show that dynamic nuclear polarization can be directed to a target protein by using a biradical‐labeled ligand. The resulting reduction of the background facilitates solid‐state NMR studies of the target protein in increasingly native environments.