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A Copper‐Catalyzed Decarboxylative Amination/Hydroamination Sequence: Switchable Synthesis of Functionalized Indoles
Author(s) -
Li TianRen,
Cheng BeiYi,
Wang YaNi,
Zhang MaoMao,
Lu LiangQiu,
Xiao WenJing
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201605900
Subject(s) - hydroamination , amination , nucleophile , catalysis , chemistry , combinatorial chemistry , copper , sequence (biology) , decarboxylation , organic chemistry , biochemistry
A copper‐catalyzed decarboxylative amination/hydroamination sequence of propargylic carbamates with various nucleophiles is described for the first time. It features an earth‐abundant metal catalyst, mild reaction conditions, and high efficiency. Further treatments of the resultant key intermediates using an acid or a base in one pot enable the controllable and divergent synthesis of two types of functionalized indoles. Moreover, experiments to demonstrate the synthetic potential of this methodology are performed.