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Inside Cover: Integrin‐Targeting Knottin Peptide–Drug Conjugates Are Potent Inhibitors of Tumor Cell Proliferation (Angew. Chem. Int. Ed. 34/2016)
Author(s) -
Cox Nick,
Kintzing James R.,
Smith Mark,
Grant Gerald A.,
Cochran Jennifer R.
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201605483
Subject(s) - conjugate , integrin , gemcitabine , cancer research , pancreatic cancer , chemistry , drug , cell growth , peptide , pharmacology , receptor , computational biology , biology , biochemistry , cancer , medicine , mathematical analysis , mathematics
A knottin miniprotein first isolated from the seeds of the squirting cucumber has been engineered to bind selectively to tumor‐associated integrin receptors. In their Communication on page 9894 ff., J. R. Cochran and co‐workers describe a knottin–gemcitabine conjugate that is over 40‐times smaller than an antibody–drug conjugate. This approach for targeted drug delivery offers an alternative strategy for the treatment of resistant tumors, such as brain or pancreatic cancer.