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Controlling Spatial Heat and Light Distribution by Using Photothermal Enhancing Auto‐Regulated Liposomes (PEARLs)
Author(s) -
Ng Kenneth K.,
Weersink Robert A.,
Lim Liang,
Wilson Brian C.,
Zheng Gang
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201605241
Subject(s) - photothermal therapy , materials science , liposome , absorption (acoustics) , nanoparticle , penetration (warfare) , visible spectrum , heat generation , attenuation , penetration depth , wavelength , irradiation , photothermal effect , optoelectronics , nanotechnology , biophysics , optics , composite material , physics , operations research , nuclear physics , engineering , biology , thermodynamics
Photothermal therapy (PTT) is enhanced by the use of nanoparticles with a large optical absorption at the treatment wavelength. However, this comes at the cost of higher light attenuation that results in reduced depth of heating as well as larger thermal gradients, leading to potential over‐ and under‐treatment in the target tissue. These limitations can be overcome by using photothermal enhancing auto‐regulating liposomes (PEARLs), based on thermochromic J‐aggregate forming dye–lipid conjugates that reversibly alter their absorption above a predefined lipid phase‐transition temperature. Under irradiation by near‐infrared light, deeper layers of the target tissue revert to the intrinsic optical absorption, halting the temperature rise and enabling greater light penetration and heat generation at depth. This effect is demonstrated in both nanoparticle solutions and in gel phantoms containing the nanoparticles.