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Back Cover: GM 1 Ganglioside Inhibits β‐Amyloid Oligomerization Induced by Sphingomyelin (Angew. Chem. Int. Ed. 32/2016)
Author(s) -
Amaro Mariana,
Šachl Radek,
Aydogan Gokcan,
Mikhalyov Ilya I.,
Vácha Robert,
Hof Martin
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201605101
Subject(s) - ganglioside , sphingomyelin , int , chemistry , ceramide , disease , neuroscience , biochemistry , biology , medicine , membrane , computer science , operating system , apoptosis
The oligomerization of β‐amyloid is thought to spark Alzheimer's disease. While sphingomyelin triggers the oligomerization (represented by gray structures on the left), GM 1 ganglioside (in green) inhibits the process, as M. Amaro, M. Hof et al. report in their Communication on page 9411 ff. These molecular insights might rationalize the development of Alzheimer's disease with the observed decrease in ganglioside concentration in the affected brain.