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Inside Back Cover: Os 2 –Os 4 Switch Controls DNA Knotting and Anticancer Activity (Angew. Chem. Int. Ed. 31/2016)
Author(s) -
Fu Ying,
Romero María J.,
Salassa Luca,
Cheng Xi,
Habtemariam Abraha,
Clarkson Guy J.,
Prokes Ivan,
Rodger Alison,
Costantini Giovanni,
Sadler Peter J.
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201605030
Subject(s) - osmium , int , dna , dna condensation , metallacycle , chemistry , cover (algebra) , cytotoxicity , stereochemistry , crystallography , biochemistry , physics , ruthenium , in vitro , gene , x ray crystallography , mechanical engineering , transfection , computer science , diffraction , optics , catalysis , engineering , operating system
Marked differences in the interactions of Os II arene metallacycles with DNA might contribute to their antiproliferative activity. In their Communication on page 8909 ff., P. J. Sadler and co‐workers describe two tetranuclear organometallic Os II complexes that show significant differences in cytotoxicity against cancer cells and behavior towards DNA condensation. They show a correlation between the organo–osmium metallacycle spacer length, stability in solution, and biological activity.