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Inside Back Cover: Self‐Assembly of Measles Virus Nucleocapsid‐like Particles: Kinetics and RNA Sequence Dependence (Angew. Chem. Int. Ed. 32/2016)
Author(s) -
Milles Sigrid,
Jensen Malene Ringkjøbing,
Communie Guillaume,
Maurin Damien,
Schoehn Guy,
Ruigrok Rob W. H.,
Blackledge Martin
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201605029
Subject(s) - nucleoprotein , measles virus , rna , sequence (biology) , cover (algebra) , virology , genome , int , biology , virus , chemistry , genetics , measles , gene , computer science , engineering , mechanical engineering , vaccination , operating system
Measles virus genomes are packaged into helical nucleocapsids, comprising thousands of nucleoproteins binding the entire genome. In their Communication on page 9356 ff., R. W. H. Ruigrok, M. Blackledge, and co‐workers demonstrate the self‐organization of recombinant nucleoproteins into long nucleocapsid‐like helices, simply upon addition of RNA, providing a simple and versatile tool for investigating assembly. Remarkably, this assembly depends strongly on RNA sequence.