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A Single Fluorescent Probe to Visualize Hydrogen Sulfide and Hydrogen Polysulfides with Different Fluorescence Signals
Author(s) -
Chen Wei,
Pacheco Armando,
Takano Yoko,
Day Jacob J.,
Hanaoka Kenjiro,
Xian Ming
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201604892
Subject(s) - hydrogen sulfide , fluorescence , chemistry , hydrogen , selectivity , rational design , photochemistry , nanotechnology , combinatorial chemistry , biophysics , materials science , biochemistry , sulfur , catalysis , organic chemistry , biology , physics , quantum mechanics
Hydrogen sulfide (H 2 S) and hydrogen polysulfides (H 2 S n , n >1) are endogenous regulators of many physiological processes. In order to better understand the symbiotic relationship and cellular cross‐talk between H 2 S and H 2 S n , it is highly desirable to develop single fluorescent probes which enable dual‐channel discrimination between H 2 S and H 2 S n . Herein, we report the rational design, synthesis, and evaluation of the first dual‐detection fluorescent probe DDP‐1 that can visualize H 2 S and H 2 S n with different fluorescence signals. The probe showed high selectivity and sensitivity to H 2 S and H 2 S n in aqueous media and in cells.