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Template‐Directed Synthesis of Porous and Protective Core–Shell Bionanoparticles
Author(s) -
Li Shaobo,
Dharmarwardana Madushani,
Welch Raymond P.,
Ren Yixin,
Thompson Christina M.,
Smaldone Ronald A.,
Gassensmith Jeremiah J.
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201604879
Subject(s) - materials science , tobacco mosaic virus , template , porosity , shell (structure) , bioconjugation , composite number , nanotechnology , polymer , metal organic framework , chemical engineering , composite material , chemistry , virus , organic chemistry , adsorption , virology , engineering , biology
Metal–organic frameworks (MOFs) are promising high surface area coordination polymers with tunable pore structures and functionality; however, a lack of good size and morphological control over the as‐prepared MOFs has persisted as an issue in their application. Herein, we show how a robust protein template, tobacco mosaic virus (TMV), can be used to regulate the size and shape of as‐fabricated MOF materials. We were able to obtain discrete rod‐shaped TMV@MOF core–shell hybrids with good uniformity, and their diameters could be tuned by adjusting the synthetic conditions, which can also significantly impact the stability of the core–shell composite. More interestingly, the virus particle underneath the MOF shell can be chemically modified using a standard bioconjugation reaction, showing mass transportation within the MOF shell.