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A Metalloregulated Four‐State Nanoswitch Controls Two‐Step Sequential Catalysis in an Eleven‐Component System
Author(s) -
Gaikwad Sudhakar,
Goswami Abir,
De Soumen,
Schmittel Michael
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201604658
Subject(s) - catalysis , chemistry , porphyrin , component (thermodynamics) , combinatorial chemistry , transformation (genetics) , photochemistry , physics , organic chemistry , thermodynamics , biochemistry , gene
The nanomechanical switch 1 with its three orthogonal binding motifs—the zinc(II) porphyrin, azaterpyridine, and shielded phenanthroline binding station—is quantitatively and reversibly toggled back and forth between four different switching states by means of addition and removal of appropriate metal‐ion inputs. Two of the four switching stages are able to initiate catalytic transformations (ON1, ON2), while the two others shut down any reaction (OFF1, OFF2). Thus, in a cyclic four‐state switching process the sequential transformation A + B + C → AB + C → ABC can be controlled, which proceeds stepwise along the switching states OFF1→ON1 (click reaction: A + B → AB )→OFF2→ON2 (Michael addition: AB + C → ABC )→OFF1. Two consecutive cycles of the sequential catalysis were realized without loss in activity in a reaction system with eleven different components.